Tsunade

Tsunade (綱手, Tsunade) is the Fifth Hokage (五代目火影, Godaime Hokage; Literally meaning "Fifth Fire Shadow") of Konohagakure — a position which she succeeded after the death of her teacher, the Third Hokage, and a major supporting character for the series. She hails from the village's Senju clan, and is also a descendant of the Uzumaki clan through her late grandmother Mito. She is recognised as one of the "Three Legendary Shinobi" (伝説の三忍, Densetsu no Sannin). Tsunade is considered to be the most powerful kunoichi in the world, and is celebrated as the greatest medical-nin of all time, credited with creating the official system which governs them.

Background
Tsunade is the first granddaughter of the First Hokage: Senju Hashirama, and his wife Uzumaki Mito, as well as the grandniece of the Second Hokage: Senju Tobirama, leading others to call her "Princess" (姫, Hime). In her childhood, she was spoiled by Hashirama, who doted on his first grandchild, and was even taught how to gamble by the great shinobi. She, along with Jiraiya, and Orochimaru are also former students of the Third Hokage. Like Team Kakashi, Tsunade and her team-mates were given the bell test, which Jiraiya failed and was subsequently tied to a log. Tsunade taunted him before leaving.

At some point, she almost killed Jiraiya after he was caught peeping on her while she was in the hot springs, breaking both of his arms, six of his ribs and ruptured several internal organs. Ever since then, Jiraiya has been very careful to suppress his perverted ways around Tsunade. Jiraiya mentions that this is one of only two times he has ever been close to death.

During the Second Shinobi War, prior to meeting the Ame Orphans, Tsunade and her team-mates fought Hanzō, who gave them the title of Konoha's "Three Legendary Shinobi" (伝説の三忍, Densetsu no Sannin), the Sannin, as a reward for surviving their battle with him while everyone else in the group died easily. On her own merit, Tsunade became famous for frequently counteracting all of Chiyo's poisons, earning the Sunakagure kunoichi's contempt for it. Furthermore, according to Jiraiya, Tsunade's unrivalled skills as a warrior and a medic were the reason Konoha won the war. However, Tsunade suffered painful losses prior to the Second Shinobi War ending.

The tragic turn of events began when younger brother was killed in action the day after his twelfth birthday, receiving their grandfather's crystal necklace which she gave him in the hopes that it would help him achieve his dream of becoming Hokage. This event resolved Tsunade to advocate for the inclusion of medical-nin to be incorporated into teams that were on the battlefield but unable to as Hiruzen informs her the conflict makes it impossible for them to utilise resources or the time to train such ninja. It was by that time that a discouraged Tsunade met Kato Dan who seconds her request of focusing on finding ways to save their comrades' lives on the battlefield.

In time, finding herself and Dan have similar ideals, Tsunade fell in love with him. As a sign of her affection, and in the hopes that this time it would help make his dreams come true, Tsunade gave him Hashirama's necklace prior to his death, with the necklace returning to her possession, rumoured as a cursed item that kills anyone other than Tsunade who wears it. Developing hæmophobia which renders her unable to take part in any more battles, the deaths of both Nawaki and Dan disillusioned Tsunade to see the Hokage title as nothing but a fool's position. With these changes of ideals, Tsunade left Konoha with Dan's niece, Shizune, taking her on as her apprentice who became one of the few people Tsunade truly trusts. Tsunade also came to own a pet pig, Tonton which she leaves mostly to Shizune's care.

In the anime, Tsunade met the Fourth Raikage, A, after he and his followers were ambushed by the ninja of the Nokizaru Group and needed her help to remove an Exploding Insects implanted in A and one of his followers. However, due to her phobia, Tsunade had Shizune carry out the surgery while she oversaw it until a bit of blood splattered on her and she excused herself from the room.

Personality
When she was first introduced, Tsunade was cynical of anyone with dreams, especially those who want to become Hokage believing that it was a futile dream. After meeting Naruto, she realises that this cynicism is insulting to the memories of both Dan and Nawaki. After seeing Naruto's conviction to become Hokage and proving her wrong in his ability to learn the Rasengan, she has a change of heart. Despite her still blunt attitude towards Naruto, she has come to care for him deeply and puts her faith in him for the future, even agreeing to take on the mantle of Hokage herself, carrying on the dreams of Dan and Nawaki. As Hokage, Tsunade has shown the same level of loyalty to the village that previous Hokage held; during the invasion of Pain, she released all of her chakra in order to save the lives of thousands of people within Konoha, at great personal risk. Tsunade also has a great deal of faith in the next generation, and sees the potential that Naruto and the rest of the Konoha 11 hold.

Tsunade typically projects a tough demeanour, even when facing great personal difficulty. She readily criticises others for their faults, such as Uzumaki Naruto's immaturity or Jiraiya's perversion, though her habits are rarely any better. Another trait of Tsunade is her monstrous, quick-temper. Many fear her because of this, such as Shizune, Jiraiya, and Sakura, the latter of whom has on several occasions warned Naruto on how to behave in her presence. Despite her temper, Tsunade is a reasonable person. She was willing to listen to Pain and even admit Konoha's past faults though he was the one who killed Jiraiya and threatening her own village. Beneath this tough exterior, Tsunade truly loves her village and its people and will at times show sympathy for others, consoling Nara Shikamaru that, while he failed his mission to return Uchiha Sasuke to Konoha, all of his team-mates survived. This is also shown when she worked hard in order to help heal Rock Lee, so that he might continue to be a ninja. In life-threatening or important situations that involve putting someone she cares for in danger, she tends to get angry with people who disagree with her plan, such as the restrictions the Konoha Elders placed on Naruto, or the argument on whether Naruto and Killer B should participate in the Fourth Shinobi War, even calling Gaara a "child" when he disagreed with her. As with all Hokage before her, Tsunade deeply believes in the Will of Fire.

Tsunade also has a firm belief that Naruto, and all jinchūriki, are people rather than instruments of war. She has always voiced that Naruto is a great ninja and should be used by the village as any other ninja would be. This value is so strong in Tsunade that she yelled at the other Kage for not allowing Naruto and Killer B to fight in the Fourth Shinobi War. Although she eventually agrees to keep the jinchūriki away from the battles, she is outraged when A decides to kill Naruto to prevent him entering the war. Tsunade then turns on A, saying that they need to use the jinchūriki in the war if they are going to win. This shows her great faith in Naruto to end the war, as she was even willing to challenge the Raikage in order to let Naruto and B pass.

As a legendary medical-nin, Tsunade truly is a role model for other medical-nin to follow. Her first priority in any situation is the lives of others. She created four rules that guides other medical-nin on the battlefield, one of which is that they should never give up on treating their comrades as long as they are still breathing. When Pain attacked Konoha, she actively took on the role of a medical-nin, healing all the injured shinobi while even having Katsuyu protect the corpses of the deceased, and did all she could to protect the village, even if it meant that she had to risk her own life. Because of this, even the persons that were later revived by Nagato, had bodies to return to. In the fight against an extremely powerful opponent like Madara Uchiha, she was the one who received the worst injuries. However, she was still the only one who was able to regain consciousness, and still put the lives of the other Kage, before her own.

Tsunade is also a compulsive gambler, a trait she inherited from Hashirama, with a losing streak due to her terrible luck. As a result, she has been elevated to a comical status as "The Legendary Sucker" (伝説のカモ, Densetsu no Kamo) because of the gross profits others have made off of her misfortune and gambling addiction. In the rare instances that Tsunade hits a winning streak, seeing it as a bad omen that eventually effects her or her comrades afterwards. However, using this to her advantage she can take steps to protect herself and her comrades.The symbol on the back of her coat, 賭 (kake), means "gamble", or "wager", as gambling is one of her favourite pastimes.

Despite Tsunade shunning all of Jiraiya's romantic advances over the years, as she was still in love with Dan even after his death, she still cared very much for him as one of her oldest friends. While he was in Amegakure investigating Pain, she bets that he will die so that her terrible luck will ensure he survives. When she finds out that he did died, she thinks back on their time together and mourns privately for the loss of her dear friend.

Because he had spoiled her greatly in her childhood, Hashirama couldn't help but wonder whether Konoha was all right upon learning she was the Fifth Hokage.

Appearance
Tsunade is a fairly tall, light-skinned woman with brown eyes and straight, blonde hair. Her hair is waist-length with shoulder-length bangs framing both sides of her face. As a child, she tied her hair in twin short pigtails before becoming Hiruzen's student when she then wore her hair in a high ponytail. As an adult, Tsunade usually ties her hair into two loose ponytails. Some time after leaving the village, she obtained a violet rhombus mark on her forehead similar to her grandmother's, which she uses as a chakra gathering point known as the Yin Seal. It will temporarily disappear when unleashing the conserved chakra and reappear after she has accumulated enough chakra. When she releases the Yin Seal, the diamond mark on her forehead opens out into a seal that usually extends to her jaws. When using the Strength of a Hundred Technique, the markings extend themselves around her entire body.

While only in her early fifties, her form is a frail and wrinkled old appearance, more so than her age would suggest. However, she maintains the appearance of her younger self through a unique and constant Transformation Technique. In her youth, the appearance she normally takes, she had a slender frame. Despite being known as flat-chested in her childhood, she now has a rather large bust; 106 centimetres in circumference, according to Jiraiya. Her beauty has been pointed out several times and she's been called the most beautiful kunoichi in the world by several characters.

She often wears a grass-green haori with the kanji for gamble (賭, kake) written in black on the back, inside a red circle. Underneath she wears a grey, kimono-style blouse with no sleeves, held closed by a broad, dark bluish-grey obi that matches her pants. Her blouse is closed quite low, revealing her sizeable cleavage. She wears open-toed sandals with high heels and red polish on both her fingernails and toenails. She also wears a soft pink lipstick. She also used to wear her grandfather's necklace in clear view on her chest, before giving it to Naruto.

Abilities
As one of the Legendary Sannin and the Fifth Hokage, Tsunade is undoubtedly one of the most powerful ninja that Konoha has ever produced. Greatly admired around the world, Tsunade is reputed to be one of the most powerful kunoichi in ninja history. She is a remarkable combatant and medical-nin and is also hailed as the world's strongest kunoichi, which has lead to many younger kunoichi to look up to her. Jiraiya commented that no one could stand equal to her in terms of combat and medical prowess.

Physcial Prowess
Tsunade's trademark ability is her immense raw strength, with which she is able to launch her targets several metres with a mere finger flick or create fissures with a single finger jab at the ground. An opponent struck by her attacks could suffer damage ranging from broken bones, ruptured organs, or even death, as Jiraiya learned for his perverted actions in his youth. In the anime, the Fourth Raikage had to resort to using a feint to throw her off-balance in conjunction with his high-speed to defeat her, as he was being overpowered. She also showed remarkable durability, able to survive the life-risking Heavenly Transfer Technique with only minor injuries in the process. She was also able to recover from a Yasaka Magatama fired at close-range.

While not her most prominent trait, she is quite fast and equally fierce in battle, having displayed high levels of quickness to the point that her opponents find her an overwhelming adversary. She was able to incapacitate Shizune with a quick strike before she could react, use the Body Pathway Derangement technique on Kabuto when he thought she was incapacitated, catch Orochimaru's sword attack with her feet moments after her hands were bound, and even intercept Manda mid-bite while lifting Gamabunta's sword. Before any of the other Kage could react, Tsunade intercepted all five of Madara's flame dragons dissipating them all. As a field medical-nin, Tsunade is highly skilled in the art of evasion.

While a medical-nin normally tries to avoid direct battle, Tsunade’s close-range combat skills have been considered unsurpassed, which she uses mainly to intimidate her opponents from approaching her in order to carry out her primary duties as a medical-nin. When entering battle directly, she is a force to be reckoned with as seen when she easily shattered Madara Uchiha's ribcage, its sword, and later knocking down a complete version of the Susanoo with single punches. She was also able to obliterate one of Madara's wood clones in a single punch. Uchiha Madara has noted that her strength far outweighed that of the Fourth Raikage.

Life Force
As a Senju, Tsunade inherited an incredible life force and physical energy passed down from her earliest ancestors. She also has immense vitality, stamina, durability, and endurance which stems from this life force, and as a direct descendant of the Uzumaki clan through her grandmother Mito, Tsunade also has the potential for a long lifespan as well as incredible vitality; a testament to the latter include her still being able to move after having her muscles torn — something Kabuto noted was an impressive and praise-worthy feat no ordinary person could achieve.

She also has a high tolerance for physical pain, as she was able to deliver a heavy kick to Orochimaru after being sliced in her shoulder, and stabbed through her chest. Throughout the fight with Orochimaru, she was able to push herself to fight on despite being tired and injured. Furthermore, her endurance was great enough to survive the normally fatal injuries of being stabbed straight through the shoulder, abdomen, and even chest to still land a powerful blow to Orochimaru. She was also able to continue fighting with extreme force against Madara's Susanoo army despite being impaled through her abdomen with two Susanoo blades. Even after being bisected, she was still able to survive the ordeal, maintain consciousness, summon Katsuyu, and feel confident she could survive long enough to heal the other Kage before being healed herself.

Chakra
Due to her heritage, Tsunade was also gifted with great supplies of chakra. She was able to simultaneously heal a large number of people with the help of Katsuyu over a long period of time, without being fatigued.

When needed, Tsunade can also release a large amount of stored chakra using Yin Seal. Upon its release, Tsunade can either use the stored chakra to facilitate the activation of one of her techniques such as the Creation Rebirth, which makes her virtually immortal in battle or simultaneously heal and protect the entire citizens of Konoha from a very powerful attack such as Pain's Shinra Tensei. She is also able to transfer chakra to others as seen when she gave Ōnoki some of her chakra in order to facilitate his large-scale Dust Release: Detachment of the Primitive World Technique and still manages to maintain the activation of her Strength of a Hundred Technique.

Even more impressive than her chakra reserves is Tsunade's control. Since a young age, Tsunade excelled in all forms of chakra manipulation; even able to maintain multiple techniques at once. Her innate talent for it allows her to gather her chakra from any part of her body with such precision and perform any technique to their maximum potential without any wasted chakra or timing. Her signature ability with chakra control is to instinctively amplify her already legendary strength with chakra control to monstrous levels, allowing her to perform feats like causing gigantic craters with a simple punch or kick to the ground, launch Gamabunta's tantō into the air and then guide it down right into Manda's mouth, and destroy Madara Uchiha's Susanoo's ribcage and its sword with relative ease. This is done by building up and releasing her chakra with precise timing upon impact, making it effortless for her to decimate any target.

Tranformation Technique
Even though she is in her early fifties, Tsunade's Transformation Technique makes her appear as if she were still in her twenties as Jiraiya noted she was not one to "age gracefully". She readily alters what age she appears in order to avoid her gambling debts. Tsunade's transformation is somewhat different from a normal transformation, as it seems to be permanent, not getting dispelled when she is slashed or injured, and she apparently does not need to exert any effort to stay transformed. She is able to maintain her transformation even while asleep. The transformation dispels when she runs out of chakra, reverting her to her natural appearance,

Medical Ninjutsu
Much of Tsunade's fame comes from her being able to perform any procedure flawlessly to cure and heal injuries that others would consider impossible or a lost cause. She can do so through the usage of no more than chakra or basic tools. She healed the psychological damage caused by Tsukuyomi, the damage done to Rock Lee's spine, and counteracted the effects of the Three Coloured Pills on Choji, something Choza stated would have been impossible if she weren't there.Tsunade has also been noted to be capable of making powerful sleeping potions that are also colourless; so much that she is the only one in the world who could spike a drink without a ninja knowing it was drugged.

With her remarkable knowledge of the human body and converting her chakra into electricity, Tsunade is capable of sending electric waves into the opponent's nervous system by striking the back of the neck. This then scrambles the electric signals within them and disrupts the way their body moves, such as attempting to move the right hand would cause the left leg to move instead, and so on. It is unknown if this is Lightning Release. In a similar manner, Tsunade has also shown the ability to use medical ninjutsu adversely and use it to harm, even kill, instead of heal. She can use a single chakra-infused strike to effortlessly cause internal damage or incapacitate a target as she did the latter to Shizune when she tried to stop Tsunade from meeting with Orochimaru. Tsunade is also able to create a chakra scalpel both for surgery and to inflict internal lacerations and even attack the internal organs.

The most extreme example of her medical prowess is her Creation Rebirth, a technique that makes use of the massive amounts of chakra stored in her Yin Seal to continuously create new cells in her body, healing any wound and even growing back missing organs. It gives her a form of "immortality" in battle that even Orochimaru expressed envy for.However, as cells can only divide and be created a set amount of times, the technique shortens her life-span. Because of the risk associated with the technique, Tsunade only uses Creation Rebirth in extremely desperate situations. This technique is considered as the absolute pinnacle of medical ninjutsu, and Tsunade developed it under the resolution of protecting those dear to her. She also created an extension of the Creation Rebirth known as the Strength of a Hundred Technique, which causes the seal to extend all the way down her body. While this technique is active, any wounds Tsunade receives will heal instantaneously, without the need to make hand seals or even a conscious effort.

Summoning Technique
Tsunade can summon slugs of varying sizes, although she has only ever been seen summoning Katsuyu. The slugs' primary abilities seem to revolve around spitting acid and splitting into smaller slugs. Tsunade apparently has a mental connection with Katsuyu, as she was able to get reports and send out messages through Katsuyu during the invasion of Pain. Tsunade can transfer her chakra to a large number of slugs over long distances. By having the slugs spread out and attach themselves to wounded individuals, Tsunade is then capable of healing multiple injuries at different locations simultaneously. This technique proved particularly helpful during the Invasion of Pain which helped Tsunade preserve the life of the villagers even after a devastating attack by the enemy forces.

Intelligance
While normally appearing carefree or short-tempered, Tsunade is a capable leader. A keen thinker, Tsunade is also highly observant and analytical, allowing her to see through most deceptions, and is rarely caught off-guard. Most commonly, Tsunade will choose the best ninja available to construct a team after looking over the assigned mission. In the anime, she was able to analyse and replicate the basic mechanics of Kabuto’s regeneration technique to aid in bettering the chances of Rock Lee's life-risking surgery being a success.

Her intelligence is most renowned as the best in the world for her expertise in all areas of medicine. She has been credited with creating the official medical-nin system and the laws that govern them. She can immediately determine what kind of injuries or illness (physical or mental) a person has from a single glance. In addition to this, Tsunade seems to have a vast knowledge of poisons and herbal medicine, as noted by Chiyo who stated that during the Second Shinobi War, Tsunade was the only one capable of countering all her poisons perfectly. She also has remarkable knowledge of the human psyche, as she was able to effortlessly undo the damage to Kakashi and Sasuke's minds inflicted by Itachi's Tsukuyomi in a matter of seconds. Tsunade has also proven to be a very capable teacher, having single-handedly trained Sakura and Shizune and passed on much of her knowledge make them become two of Konoha's best medical-nin and field support.

In battle, she has shown great ingenuity, able to quickly pick up on her opponent's fighting style and battle pattern to better avoid damage and plan her attacks around that. These traits are to keep herself alive in battle so she may heal her team-mates; things she drilled into Sakura while training her. Her mental fortitude is also noteworthy, as she overcame her paralysing fear of blood through willpower alone, something every eyewitness found miraculous.

Other Skills
In the anime, Tsunade demonstrated noticeable skill in a variety of other areas. When dealing with the Legendary Stupid Brothers, her skill in genjutsu was great enough to bind the immensely strong duo at once. She was also able to use Space–Time Ninjutsu to send one of Katsuyu's divisions to Team Three's location despite the great distance. Tsunade is also well-versed in fūinjutsu, capable of developing an S-ran seal that continuously stores up chakra for various reasons including using the high-level techniques such as the Creation Rebirth technique which she also created. In the anime, she designed the Four-Corner Sealing Barrier which can be used to seal a tailed beast from scratch.

Search for Tsunade Arc
After his failed invasion of Konoha cost him his arms in the aftermath of his fight with Hiruzen, Orochimaru sought out Tsunade to heal his arms. Declining at first while noticing is arms, Kabuto Yakushi complemented Tsunade's talent while saying that she's the only one in the world who can cure Orochimaru or kill him. Inspecting the injury, Tsunade learns that it was inflicted on her former team mate by Hiruzen, whom Orochimaru killed in battle. Shocked upon hearing that revelation, Tsunade attempts to Orochimaru before he offers to use Impure World Reincarnation to bring back Dan and Nawaki as payment for her services. Seeing that she was tempted by this offer, Orochimaru left her a week to consider his proposal.

Soon afterwards, Tsunade was approached by Jiraiya, who wanted her to become the next Hokage. After she disrespectfully turns down the offer, an enraged Naruto challenges Tsunade to a fight for her ridiculing of the title. Though she easily beats him in the match, Tsunade shows interest at Naruto's attempt of using the Rasengan and makes a bet with him: she would give him Hashirama's necklace if can could master the technique within a week with and he would give her all the money he had in his frog wallet if he fail. Naruto accepted the bet, and Tsunade kept a careful eye on Naruto's progress throughout the week while contemplating Orochimaru's offer. When the week was up, and Naruto appeared to have failed in mastering the technique, she drugged Jiraiya so he would not meddle and went to meet Orochimaru.

Though it seemed she was able to heal Orochimaru, having him promise not destroy Konoha once his arms were healed, Kabuto exposes Tsunade's actual intent to kill Orochimaru. Her motives known, Tsunade revealed that she knew Orochimaru has no intention of honouring his promise to leave Konoha alone, and that she couldn't bring herself to let him attack the village again even if it meant seeing Nawaki and Dan again. While she had tried to forget this fact over the years, Naruto's determination and desire to be Hokage reminded her of their dreams, and she had decided to do whatever was necessary to protect those dreams.

With that, Tsunade attacked Orochimaru, though Kabuto fought her in his place. However, realising that he is completely outmatched, Kabuto slits his wrists to use Tsunade's hæmophobia against her before Shizune and Naruto came to her rescue. While he and Shizune were easily defeated, despite Tsunade telling him to run, Naruto was able to overcome his injuries and manages to defeat Kabuto with a perfected Rasengan in his effort to protect her. As Naruto collapsed and in critical condition, Tsunade manages to heal him and giving him Hashirama's necklace in hope he would become a Hokage.

Orochimaru, worrying about what kind of threat Naruto might become when he got older, attempts to kill him, though Tsunade blocks that attack with her body. When inquired as to why she was protecting Naruto, Tsunade replies that Naruto would someday be Hokage, and that she would not allow him to die before that happened. With that, Tsunade accepted the title of Fifth Hokage while overcoming her fear of blood to eliminate Orochimaru. Joining forces with the still drugged Jiraiya, the two attacked Orochimaru. After a battle of summons, Tsunade dealt the finishing blow to Orochimaru. Defeated, Orochimaru escaped, vowing to destroy Konoha once he'd healed himself. Once Naruto recovered, the group returned to Konoha where Tsunade begins her term while secretly believing that Naruto would someday become her successor. Also, like with Nawaki and Dan before Naruto, Tsunade gives him a kiss on the forehead to show her faith in him.

Sasuke Retrieval arc
Soon after arriving in Konoha to take her place as Hokage, Tsunade healed the mental injuries inflicted by Uchiha Itachi's Tsukuyomi on Hatake Kakashi and Uchiha Sasuke. She also gave a grim prognosis on Rock Lee's condition. She stated that the only procedure that could allow him to return to duty as a ninja was one that she alone was capable of performing, and it only had a fifty percent success chance that could prove to be fatal for Lee. Not wanting to take such a risk, Tsunade advised Lee that it was best that he retire as a ninja and find another profession. In the anime, while Lee is struggling to decide what he should do, Tsunade looks into ways to improve his chance of survival. Thinking back to how she had seen Kabuto withstand Naruto's Rasengan, Tsunade used Kabuto's technique as an inspiration to expand on the life-threatening operation and improved Lee's chances of survival from fifty to fifty-eight percent. Lee finally agreed to undergo the procedure and survives.

When Sasuke defected from the village so that he could go to Orochimaru, Tsunade was forced to send out a group of genin to try and stop and retrieve him, due to lack of manpower. She also used Konoha's reacquired alliance Sunagakure to call in a favour for reinforcements, hoping to give the retrieval team some back-up. Despite her efforts, the group ultimately failed, and Tsunade helped in healing their mortal injuries, bringing them back to full health. She was particularly instrumental in the healing of Chōji, mixing the antidote to the side effects of the Three Coloured Pills that she got from the medical encyclopaedia kept by the Naras; a fact Choza gratefully stated. In the aftermath of Sasuke's betrayal,Haruno Sakura asked to become Tsunade's apprentice, which Tsunade gladly accepted.

Pre-Shippuden Filler arc
Tsunade appeared in numerous filler arcs, though she typically did nothing more than sending others out on missions, occasionally trying new ways of deciding who would go on a specific mission. Her goal during the filler arcs was to keep Naruto busy until Jiraiya came back, to prevent him from going after Sasuke himself. When the Legendary Stupid Brothers escape from prison, she convinces them to surrender with a quick display of genjutsu and her strength. In another filler, she summoned Katsuyu to deal with some impersonators of Rock Lee and Gai, who had entered the village.

Naruto Shippuuden (Part ll)
During the next few years while Jiraiya and Naruto were off training, Tsunade continued her duties as Hokage and her tutelage of Sakura as a field medical-nin. Also during this time, the Hokage Monument was altered to include Tsunade's face in chronological order.

Rescue the Kazekage arc
While taking care of reports for genin missions, Tsunade learned that Jiraiya and Naruto had returned. Tsunade then decided to test Naruto's, as well as the now chūnin Sakura's, growth as ninjas by pitting them against their former jōnin-sensei Kakashi. After the two succeeded in their challenge and received praise from Kakashi, Tsunade officially made them a unit under their old name "Team Kakashi".

Later, while deciding on Team Kakashi’s first mission, Tsunade received word from Sunagakure that the Akatsuki had abducted Gaara, now the Fifth Kazekage. Out of respect for the Konoha-Suna alliance, Tsunade sent Team Kakashi to assist. A few days later, Tsunade had a bad premonition when she discovered she won a major sweepstakes and sent Team Guy as backup for the mission in response.

Sasuke and Sai arc
After Team Kakashi and Team Guy returned from rescuing Gaara, Tsunade was informed that the fallen Akatsuki member Sasori had intended to meet an agent of his working within Orochimaru’s ranks. Seeing the chance to get intelligence on Orochimaru, Tsunade decided to have Team Kakashi capture this spy. Unfortunately, the elders were against letting Naruto go out on dangerous missions as the Akatsuki sought to capture him. Tsunade sternly voiced her belief in Naruto. The elders ultimately yielded under the condition that Tsunade added one of the men of Danzō Shimura, Hiruzen's fierce rival and leader of the ANBU Root division, to Team Kakashi. With Kakashi currently hospitalised, Tsunade also added an ANBU agent codenamed "Yamato", mainly for his ability to utilise the Wood Release and its ability to suppress the tailed beasts, should Naruto get out of control. She also warned Yamato to keep an eye on Danzō's addition to the team, Sai.

After Team Yamato returned, having failed their mission but gained new information on Sasuke, Tsunade surmised that Sasuke’s immense growth may have come from the assistance of Orochimaru’s use of kinjutsu and Kabuto’s medical ninjutsu. Tsunade was also troubled to learn that Danzō, in his self-righteous ideals, was willing to give the enemy top-secret information in an effort to complete the mission as Sai was instructed to give Orochimaru ANBU data should they meet.

Twelve Guardian ninja arc
In the anime, word reached Konoha that several villages on the Fire Country’s borders were being attacked. Tsunade sent several teams to investigate. She also sent Team Yamato to investigate several tombs near the Fire Temple being disturbed. When Team Yamato returned, they informed Tsunade that the tombrobbers were apparently after corpses of four former members of the Twelve Guardian Ninja. Team Yamato also brought an unofficial new member to the team from the Fire Temple to replace an injured Sai, a young monk named Sora. Tsunade also received a message explaining Sora’s troubled past and unusual powers that he is not able to control that lead to great damage of the Fire Temple.

Later, Tsunade had the ANBU apprehend Danzō due to his recent and possibly treacherous actions and ninja from the Amegakure with Danzō. Before she could interrogate the man, the elders arrived. They revealed that the Rain ninja was a double-agent working for them. The elders explained the same tombrobbers Team Yamato encountered may also be after Sora. The elders and Danzō came to the conclusion they should confine or eliminate him. Before Tsunade could voice her refusal, Sora was found spying on them. Convinced that Tsunade wanted to eliminate him, Sora became furious at her. Sora then asked Asuma if it was true that Asuma killed his father Kazuma. When Asuma sadly admitted it, Sora’s rage unleashed his hidden powers and was able to escape.

Later while Tsunade was deciding what to do about Sora, the village had a complete power-outage, thanks to the tombrobbers. They arrived in the village and surrounded it in a giant barrier. They voiced their distain for Konoha as they viewed as an imbalance to the Fire Country’s power and sought to destroy the village. As they overwhelmed Konoha’s forces with a zombie resurrection technique due to most of the ninjas being outside the village, Tsunade discussed the situation with Shikamaru. It was determined through Asuma that the tombrobbers intended to destroy the village with the deadly Limelight technique through the four resurrected guardians.

After the tombrobbers were defeated and Sora was purged of his powers, Tsunade forgave Sora for his mistakes and was allowed to leave the village in peace.

Hidan and Kakuzu arc
Later, when two Akatsuki members entered the Land of Fire — namely Hidan and Kakuzu — Tsunade mobilised the Nijū Shōtai to look for and if possible, capture the Akatsuki duo. While capture never came to be possible, the Akatsuki members were both defeated. Tsunade later performed an autopsy on Kakuzu, and found Naruto's newest technique, Wind Release: Rasenshuriken to be too dangerous for use, based on the damage done to Kakuzu's body and Naruto's arm. She explained that the attack had struck at a cellular level, causing extensive damage to the both of them, and regretfully told Kakashi and Yamato not to allow Naruto to use the technique again.

Three Tails arc
In the anime, after finishing her autopsy on Kakuzu, Tsunade received a report from a dead ANBU captain about Orochimaru and Sasuke's whereabouts. She called for Kakashi, and put him in charge of Team Kurenai to investigate. Because the mission involved a chance of finding Sasuke, Tsunade tried to keep Naruto from finding out about it. He found out anyway, so Tsunade didn't hesitate to send him as back-up.

Later, Tsunade received news that Team Kakashi had encountered the Three-Tails. Deciding that they needed to capture the beast quickly, as to not let it fall into enemy hands, Tsunade ordered Tenten, Rock Lee, and Yamanaka Ino to aid Team Kakashi in sealing the beast. Before sending them out, Tsunade made a large and special scroll to aid the team in sealing the beast. She also decided to summon and send out Katsuyu for further assistance. When the forces they sent continued to have problems with the sealing, Tsunade called them back to Konoha, and sent some ANBU to replace them. After she heard about the ANBU losing contact with Konoha, and the disappearance of the Three-Tails, Tsunade suspected that Akatsuki were somehow involved.

Itachi Pursuit arc
Tsunade assigned Team Kakashi and Team Kurenai on a mission to find Uchiha Itachi in the hopes that it would lead them to Sasuke. Jiraiya later comes to inform her that he had found the location of the leader of Akatsuki. Despite her insistence for his location to formulate a surprise attack, Jiraiya instead invites Tsunade for drinks, which she ultimately ends up agreeing to it. While in Shushuya, Jiraiya reveals the details of the Akatsuki's leader and that he was in Amegakure and the difficulty of getting into the village. As Jiraiya declares that he would infiltrate the village on his own, Tsunade objects but Jiraiya reminds her that he is one of the Legendary Sannin and what that meant. After the two reminisce a bit about Naruto and his parents. Tsunade tells Jiraiya to come back alive and if he needed help to send a toad and she'd come in person to back him up. On departing, Jiraiya tells her to remain cautious of Root.

Tsuchigumo Kinjutsu arc
In the anime, word reaches Konoha that the Tsuchigumo clan's fort protecting a powerful forbidden technique was under attack. With Team Kakashi and Team Kurenai being the closest, Tsunade sent Katsuyu to inform them of their mission to aid the Tsuchigumo clan, in accordance with the peace treaty the Third Hokage made with them. Tsunade later receives word from the teams that they and the clan have considered destroying the technique to end the possible danger it can cause.

Invasion of Pain arc
When word reaches Konoha of Jiraiya's death, Tsunade makes the village's top priority to analyse the clues Jiraiya gave them to uncover Pain's identity. While the likes of Shizune, Ibiki, and Shikamaru are hard at work, Tsunade allows herself an opportunity to cry for her old friend. Naruto, just as badly affected by Jiraiya's death as Tsunade, went away to train, both of them knowing that he was Pain's next target.

When the invasion of Pain began, Tsunade tried to send word for Naruto to return home. She was stopped by the Konoha Council, who feared his capture by the Akatsuki. However, Tsunade insisted that they must have faith in Naruto, along with the rest of the next generation, and so they relented. Tsunade began issuing orders for the village's defence, placing extra protection around those still working on Pain's secret. She summoned Katsuyu, and had her divide and seek out every villager so that she could protect and heal them remotely.

While sitting in the middle of a seal guarded by ANBU, transferring her chakra to Katsuyu, she was found by Pain's Deva Path, whom she recognised as one of the orphans Jiraiya had trained in the past. Tsunade refused to tell it where Naruto was, proclaiming that Akatsuki was just a terrorist group and that Konoha would not give in to their demands. Despite this Pain discovered Naruto's location through other means, the Deva Path resolved to make Tsunade see what Akatsuki's true goals were, by witnessing peace.

When the Deva Path jumped into their air, Tsunade and her ANBU followed only for the village to be destroyed. In the few moments between when the destruction began and ended, Tsunade poured all her chakra into Katsuyu in order to keep the villagers safe. In the aftermath, she confronted Pain, who attempted to kill her with his Asura Path. It was stopped by Naruto, who informed Tsunade that he would personally deal with Pain. Leaving a clone of Katsuyu with Naruto, Gamakichi carries Tsunade to Sakura. Having used up almost all of her chakra, Tsunade's elderly form resurfaced, she then falls into a coma and does not see Naruto's victory over Pain.

Konoha History arc
Choji and Naruto bring lunch to Sakura and Shizune. Then Naruto leaves to assist rebuilding Ichiraku. When Choji says the saying, "Fools never catch a cold", Sakura has a flashback of catching Naruto's cold. When Sakura sees Tsunade at her office, she collapses which Tsunade claims Sakura has an illness known as a chakra virus. It was an illness long ago in another village that would turn chakra into a terrible flu and Naruto recently went to that village for a mission. Tsunade, not wanting to scare the villagers orders Shizune and a team of medical ninja to capture Naruto.

The medical-nin try to capture Naruto, thinking they are after him for overeating ramen but he escapes them every time. The next morning, Naruto finds the village deserted and gets shot at from a distance from one of the medical ninja. Naruto finds the ninja and questions him. The medical ninja tells him that the villagers have evacuated and that Tsunade ordered Naruto's capture with explaining the reason. Shizune and a team of medical ninja arrive and chase after Naruto who tries to locate Tsunade. Naruto finds Tsunade but tries to corner him with a bunch of tall walls. In each sides are Choji, Kiba and Tenten who are also ordered to capture Naruto though the groups of shadow clones they defeat do not contain the real Naruto.

The real Naruto flees to Konoha Hospital, distracting Aburame Shino with one last another shadow clone as he hides in one of the rooms. The room Naruto is in happens to be where Sasuke is still recuperating after their Land of Tea mission. Learning Naruto was the source of ruckus occurring outside, Sasuke kicks Naruto out of his room with medical ninja grabbing him. After getting results from Naruto, Shizune tells Tsunade that he doesn't have the chakra virus but sneezed due to pepper he had in his pocket and Sakura just has an allergic reaction from Naruto's sneeze. After he is released, Naruto demands an apology from Tsunade for her mistake though she covers it up by claiming the entire event as an "emergency drill".

Tsunade assigns Naruto to capture Mr. Ostrich who escaped again into Training Ground Zero. Unlike last time, Mr. Ostrich trained himself into becoming a nindachō. Tsunade has Kotetsu Hagane captain of the team of Naruto, Shino and Lee. Izumo Kamizuki learns of Kotetsu's mission and whines about not being with Kotetsu which annoys Tsunade. Kotetsu has Shino locate Mr. Ostrich with his kikaichū and the team manages to find him who laughs at Naruto. Shino has Naruto to try and distract him while he would surprise him with his bugs. Naruto makes an insult about Mr. Ostrich's father but makes a fool of himself instead. Shino's bugs get eaten by fly traps and the ostrich makes an escape. Lee runs after him but runs into a boxing kangaroo. Mr. Ostrich runs to Naruto and surprises him with his ability to speak. Naruto, Kotetsu and Lee all struggle in fighting against the powerful animals and decide to retreat.

Kotetsu decides for the team to longer hold back against them when suddenly Mr. Ostrich and the kangaroo find them. Mr. Ostrich, who now names himself Condor, is tired of humans domesticating animals and formed a team of ninja animals. Shino tries to sneak his bugs to Condor again but they are eaten yet again by an anteater that is part of Condor's team. The team battles against the animals, who prove to be a handful for them. Kotetsu decides to use his Conch Shell Mace to fight Condor who is knocked down by his powerful kicks. Izumo arrives and yells at Kotetsu to run from Condor's attack. Izumo uses his Water Release: Starch Syrup Capturing Field to trap Condor and Kotetsu manages to strike down Condor. The rest of the team manages to defeat the other animals they were fighting. Izumo arrived to help out Kotetsu but resulted in leaving a stack of Tsunade's paperwork unfinished. Kotetsu decides to make it up by finishing the work for him. The flashback ends and Naruto finds Condor who is surprised to see he escaped yet again and chases after him.

Lee arrives at Tsunade's tent and asks Sakura how she is feeling though Sakura nods her head no. Lee brought a bottle of medicine Guy made for her to get well and has a flashback of when Tsunade told him he could no longer become a ninja. Naruto and Sakura find Yamanaka Ino at the hospital who tells them they have a mission together. They say their hellos to Lee in his room. Lee accidentally drops his youth drink bottle that Gai made for him but catches it and drinks it all, putting Lee is dismay. With the drink, Lee would be able to recover a little faster. Naruto decides to go see Guy and have him make another drink. Guy appoints Naruto to a mission to go to Mount Jofuku to retrieve the Jofuku Flower, a medicinal herb said to cure any illness and the missing ingredient in the medicine he is making. Before setting off, Naruto puts on the green jumpsuit that Guy gave him.

Naruto meets Sakura and Ino at the village gate who were waiting to leave with Naruto to their mission. Naruto tells them of his mission at Mount Jofuku which is also the place of his team's mission. The team takes a break at a small tea soup where the old lady there warns them of Jofuku Forest that has ghosts of dead ninja wandering about. The team head to Jofuku Forest where they find a large sign blocking a path. Naruto decides to go through it with Sakura and Ino following him, having no choice. Naruto finds the Jofuku Flowers but upon pulling them causes some sand appearing that forms into Gaara after the mention of him from Ino. The team are shocked to see "Gaara" and decide to retreat but suddenly the Gaara impostor starts attacking Naruto, having the same abilities as the real Gaara. Ino tries her Mind Body Switch Technique on the impostor but cannot sense a consciousness in it. Naruto destroys the Gaara impostor with the Uzumaki Naruto Combo and a Rasengan. Suddenly they are approached by an old medical ninja from Konoha named Furofuki who is doing research in the forest.

Sakura asks Furofuki who or what was the Gaara impostor and she tells it was a Jofuku Flower, which assumes the form of the nemesis of whoever pulls it. They give Furofuki the letter that they were assigned to do and are given another mission by her to take loads of Jofuku Flowers back to Konoha. With final ingredient made, Guy is able to finish the medicine and makes a bowl full of medicine balls for Lee. Lee is shocked to hear that Sakura and her team did this and decides to recover as soon as possible. While Lee starts devouring the horribly tasting medicine balls, Guy does 1000 push-ups, not wanting Lee the only one to suffer and the flashback ends.

Chikara arc
Tsunade tasked Team Kakashi with the mission to investigate the massacre of the Tonika Village. She noted that she wished that she could send more persons along with them, but currently they were elsewhere investigating a grave robbery and the theft of Hidan's Triple-Bladed Scythe from the Nara clan's forest. She later showed Kakashi, Gai and Shikamaru the results of Team Kakashi's observations and sends them out to assist them.

Adventures at Sea arc
At a meeting held by the Hyuga clan regarding the impending war, Hyuga Neji is appointed as the commander of the clan on the frontlines by Hyuga Hiashi which shocked some of the members. Hinata later meets with Kurenai where she is told by Shikamaru that he and quite a few of the other members of the Konoha 11 had seen Naruto since he left the village and that Tsunade was looking for her.

Hopeful that Tsunade had in fact requested her to go on a mission so she could see Naruto she goes in search of her only to be disappointed. She along with the other females of the Konoha 11 and Shiho are later invited by Tenten to a girls night out at Yakiniku Q. Somewhat saddened that he wasn't invited, Choji comes up with the idea of a guys night out at the same place. The two groups talk about Naruto and the past, reminiscing about the first Chūnin Exams. The girls are later joined by Shizune and a moderately intoxicated Tsunade. Tsunade attempts to apologise for how she dismissed Hinata earlier but Hinata tells her it was fine as she knew what she had to do. The next day during her training with Neji she tells him that she bore no ill will towards him for her father's decision and that he was the right person to lead them in the war.

Cofining the Jinchuriki arc
While Tsunade remained in a comatose state, Shimura Danzo was chosen to replace her as the Candidate Sixth Hokage. However, he was killed by the now-international criminal Uchiha Sasuke after the Kage Summit and the village prepared to make Hatake Kakashi the new Hokage, but Tsunade woke up before the appointment could be finalised. Tsunade learned of everything that happened while she was in her coma; the start of the Fourth Shinobi War, the Shinobi Alliance, and the "identity" of Tobi. After replenishing her chakra levels, she convened a war council to prepare the village for the impending war. In the anime after the war council, she calls a private meeting in her temporary office as they discuss the impending war.

Three days later, Tsunade goes to Kumogakure to meet with the other heads of the Alliance. She is warmly greeted by the Fifth Mizukage while the Third Tsuchikage suggests she retire so that she can finish recuperating. When they get down to business, Tsunade learns that the other Kage have decided to send Naruto and Killer B into hiding to keep them safe from Akatsuki. Tsunade argues against this, believing that the jinchūriki will be valuable assets in the coming war. The other Kage insist that it's for the best and Gaara reminds her that she must also take others' views into consideration. She eventually agrees with their decision, albeit reluctantly. Later, she helps organise the joint armies, placing particular interest in the Logistical Support and Medical Division and the Intelligence Division. In the anime after the meeting with the other heads of the Alliance she requests the Fourth Raikage that B teaches Naruto to achieve the control over the Nine-Tails.

Fourth Shinobi War arc
Later, Tsunade remained at headquarters with the Raikage and the Tsuchikage, providing input when needed. When the First Division engaged several reincarnated ninja, Tsunade was disturbed by the possibility that Dan may be amongst their numbers. She is later surprised by news that enemies on the battlefield contained the Nine-Tails' chakra.

When more news reached headquarters of Naruto and B's escape from their confinement, the Raikage asked Tsunade to help him deal with them. She summoned Katsuyu and leaves a clone at headquarters, taking another Katsuyu with her so that they could keep up-to-date on any urgent matters at headquarters. When they intercepted Naruto and B, Tsunade was amazed by Naruto's subjugation of the beast. Naruto appealed to Tsunade to let him and B pass, but she informed him that she could no longer act independently, and must do what was best for the Alliance. Naruto tries to escape but was stopped by the enraged Raikage, who voiced his willingness to kill Naruto and B if they would not submit. Upon hearing this however, a shocked Tsunade, told him that she would not allow him to do any such thing.

Turning to oppose the Raikage instead, she remembered Naruto's words, that he would not die until he became the Hokage, and argued that even if Naruto being killed delayed the enemy's plan, that it was unlikely that another jinchūriki would have the same success as Naruto had with controlling the Nine-Tails, and going against A's instructions, she would allow them to enter the battlefield. When despite this it seemed as though A would not be swayed, Tsunade was intent on fighting him, but, as it turned out, A was testing Naruto one final time and then agreed to let him and B continue on to the battlefield when the young man proved himself.

Upon returning to headquarters, Tsunade reviewed the data from the Logistical Support and Medical Division autopsy and was disconcerted by what Madara Uchiha and Orochimaru had done with her grandfather's DNA, and concluded that harvesting the cells was probably what had allowed Madara to live for so long. When A asked if there were any hints on how to defeat Madara, Tsunade replied saying that Madara may in fact be the true definition of the word "immortal". She then told Shikaku to inform Naruto and B about the White Zetsu Army clone's transformation ability.

Having heard a report from Inoichi about the progress that the Alliance was making on the battlefield after Naruto's release, Shikaku commented that they were gaining the upper hand. At this, Tsunade smiled at A triumphantly. They are subsequently told, however, that a new chakra had been sensed in the region of the Fourth Division. This was confirmed to be the real Madara Uchiha which sent those at headquarters into confusion. Mabui inquired about the reason behind the masked man assuming the name "Madara", to which Tsunade responded that, even more than a name, Madara was an ideal which struck fear into people from just the simple idea of him. A sudden tremor was felt, and after hearing the report from Inoichi that a meteorite had been dropped on the Fourth Division, and hearing Ao report that the lives of several shinobi had been lost, Tsunade decided to head out to the front-lines of the battlefield personally.

Adamant about her decision, she told Mabui to prepare her Heavenly Transfer Technique to transport her there. Mabui protests however, saying that her technique was not intended for use on living organisms. She comments that the Third Raikage was the only one able to withstand her technique because of his special body. Shikaku also tried to dissuade Tsunade, telling her that it was a huge gamble regardless, and reminded her that she wasn't so lucky when it came to gambling so they should have the Hokage Guard Platoon use the Flying Thunder God Technique to transport her instead.

Though she admits that she is bad at betting money, she argued that it was a different matter when it came to her life, citing that as the reason why she’s still alive also claiming that they should use the Flying Thunder God Technique to transport Mei, since they needed a way to deal with Madara's Fire Release techniques, and that she would simply use her Strength of a Hundred Seal to heal any damages. Despite Mabui's insistence, A told her to prepare the technique for two, as he would be accompanying Tsunade.

Mabui eventually conceded to the order, and used her technique to send them to the battlefield. Upon their arrival, Tsunade attacked Madara immediately with a kick sending him flying while A attacked Mū simultaneously. Sustaining some minor injuries in transit, she released the seal on her forehead and used her Creation Rebirth technique to heal herself. Standing up alongside all the other Kage, she faces Madara prepared to fight.

As the battle with Madara began, Tsunade stated that first she would heal Ōnoki and Gaara's injuries, and asked Mei and A to hold off Madara while she did so. As she was healing them, Naruto questioned her on why she hadn't collapsed after using Creation Rebirth when she arrived. Tsunade responded, telling him that this instance is different compared to the scale she had to use it on during Pain's invasion, as this time she was only healing her own injuries which were nowhere near as bad as the injuries she healed during Pain's invasion. Naruto asked to be healed despite being a clone, so he could join the battle as well, but Tsunade told him that there was no need for that — Ōnoki then went on to explain that the war was no longer just about protecting him. After being completely healed, Ōnoki and Gaara join the battle just in time to protect everyone from Madara's attack. As Madara is downed by the Kage's combined assault, Naruto turned to Tsunade, but was told by Ōnoki that this battle is no longer Naruto's to fight. Tsunade told Naruto that they could only win if they defeat both Madaras — stating that while they protected him from the reincarnated Madara on this side, he needed to protect them from Tobi. With that, Tsunade and the rest of the Kage give Naruto a message, telling him simply to "win" as the clone dispersed.

As the battle continued, Tsunade took up a supplementary role and hung behind the main battle to heal the other Kage whenever they got injured. As Madara used the Wood Release: Advent of a World of Flowering Trees technique, Tsunade was visibly shocked to see him use her grandfather's technique before calling out to Gaara, who suspended them above the attack. She then told the other Kage to ensure they didn't inhale any of the pollen, but the Kage however were ambushed and knocked back to the forest floor by Madara's Susanoo. Inhaling the pollen, they fell unconscious until Ōnoki managed to destroy the trees and part of Madara. Tsunade later stared in shock as she sees the face formed from her grandfather's DNA jutting out of Madara's now-exposed chest.

As Madara regenerated he asks Tsunade if she was a descendant of the man on his chest. After this was confirmed, he declared that she would be the first to die. As Mei states that attacking the medical-nin in a team was a common tactic that they'd never allow, Madara tells them that it was not because she was a medical-nin, but because she was a Senju descendant whom he has deemed to be weak in comparison to her grandfather, who could also use medical ninjutsu. After Madara recounted Hashirama's skill with medical ninjutsu, stating that Tsunade's paled in comparison, Tsunade stated that even though she was a descendant of Hashirama who could not use Wood Release, and admits that her medical ninjutsu paled in comparison to her grandfather's — whose techniques did not require hand seals — she stated that Madara was wrong in thinking that she was weak. She then went on to declare that more so than the abilities she did not inherit from her grandfather, she inherited his Will of Fire, which Madara should not take so lightly.

As she denounced Madara's claims, she told him of the four rules she created for her students and medical-nin alike stating that she was the only one who was allowed to break these because of rule number four: only those that had mastered the Creation Rebirth technique were allowed to break the other three rules and engage directly in battle. With this she completely released her Strength of a Hundred Seal, activated the Strength of a Hundred Technique, and confronted Madara — cracking his Susanoo's ribcage with a single punch. As Madara counter-attacked with the Fire Release: Great Fire Destruction technique, Mei intercepted this and countered with the Water Release: Water Formation Pillar technique and then sent Madara flying into the air with the Water Release: Water Dragon Bullet Technique. With this, A, Ōnoki and Tsunade prepared a twofold attack which sends Madara plummeting into the ground. Barely giving him time to relent, Tsunade chided him again about inheriting the Will of Fire as opposed to something physical wondering whether or not he was even listening.

Attacking once again, Tsunade was able to land a blow to Madara directly which destroyed his entire right side. Seemingly incapacitated enough, Gaara bound and sealed him. As Tsunade congratulates the other Kage, her face widened in shock as one of Madara's Susanoo Swords emerge from the ground and impaled her. As Madara emerges from a root, he revealed that what they had sealed was nothing but a mere wood clone and that when Hashirama used it during their battles, he was the only one that was able to distinguish the clone with the use of his dōjutsu.

Just as Madara sets his sights on the other Kage — believing her to be dead — Tsunade broke the sword lodged in her abdomen and, in one fluid motion, swung it at him, but Madara managed to block it by using his Susanoo's ribcage. Tsunade was then sent flying back when Madara attacks her with his Yasaka Magatama technique — crashing into a wall. She emerged seemingly unaffected by his attack as her wound heals. Madara praised her for this, and compared her technique to Hashirama's, though she admitted that she had just intended to create an opening for an attack, but Madara was also able to nullify Ōnoki's sneak attack.

Jeering Madara, Tsunade stated that it was true that he was able to outwit them with his wood clone, but, that at the same time it could be said that they had cornered him into using the clone. This causes Madara to use the Multiple Wood Release Clone Technique, sending five clones to fight each of the Kage. With this he asks them whether or not they'd prefer the clones use Susanoo, much to the Kage's collective shock.

As the battle raged on, Tsunade sent one of the Susanoo-clad clones plummeting into the ground. After A berated her increasingly reckless actions Tsunade reminded him that she had already stated she would bet her life and removed the two broken Susanoo blades from her abdomen. This however, caused her some pain and she coughed up blood. Spurred on to stand and fight by Ōnoki once more, the five Kage regroup and launch a new strategy with Tsunade transferring some of her chakra to Ōnoki in order to facilitate his large-scale Dust Release: Detachment of the Primitive World Technique which results in them taking out all twenty-five clones in one shot.

After a follow-up combo attack from A, Mei, and Gaara, Madara acknowledges that they are indeed worthy of their Kage titles, and manifests his complete Susanoo. After Susanoo is completed, Tsunade along with the other Kage stared in shock at the humongous construct. Now realising the difference in power between the Kage and Madara, Tsunade wondered whether her grandfather really fought and defeated someone like that before being knocked down by a swing of Madara Susanoo's sword. As they regained their footing, she and the other Kage stood to face Madara once more. As Madara prepared to deliver another devastating blow with his sword, Tsunade formed a seal, seemingly prepared to counter the attack. However, Madara's attack is halted as he was then enveloped by a light of sorts and it appeared as though he was about to be released, she wonders who could possibly have stopped the Impure World Reincarnation since the Alliance was still in the process of searching for Kabuto.

Ōnoki cautioned his fellow Kage as Madara made a last desperate attempt to attack them, using the Fire Release: Dragon Flame Release Song Technique. Intercepting the attack, Tsunade dissipated the flame dragons with her bare hands. Her arms are burned in the process, and though Strength of a Hundred Technique was able to repair the damage, the technique wore off shortly afterwards and her Strength of a Hundred Seal disappeared as her chakra reserves depleted. As she began to lose consciousness while still in mid-air, Madara prepared to impale her with his Susanoo's sword once again, but Tsunade miraculously dodged the blow.

As she wondered what it was that saved her, she heard a voice inside her subconscious where she saw Dan standing before her. He commented that she hadn't changed since he was alive, still taking risks in combat, but then thanked her for achieving what he didn't by becoming Hokage and apologises for bringing so much pain into her life with his death. He stated that he would be waiting for her on the other side, but insisted that she not come too soon, as she was his dream itself. He left her with a kiss on her forehead, reminiscent of the one she gave him decades before, grateful that he was able to protect her, even if it meant being used in the Impure World Reincarnation. Before departing, he gave her the remainder of his chakra and as the Strength of a Hundred Seal reformed, Madara commented that she has regained her vitality and wondered how that could be, to which she simply replied saying she had met an old friend. With Madara having broken the Impure World Reincarnation technique's contract with the summoner, however, the Kage now faced an opponent with limitless chakra, and an immortal, uncontrolled body.

Despite the Kage's attempts to stop Madara, they ultimately failed and were left heavily wounded, with Tsunade bisected. Despite her condition, Tsunade was able to muster enough energy to summon Katsuyu. Distressed by its master's condition, the slug immediately stated that it would put her back together. Tsunade instead asked Katsuyu to first bring the heavily injured Kage to her, stating that she would save them first before healing herself. Later, she was approached by a revived Orochimaru, who remarks about her current state. He was joined by Karin and Suigetsu Hōzuki. Orochimaru ordered Suigetsu to aid Katsuyu in re-attaching Tsunade's bisected body. Meanwhile, Karin allowed Tsunade to bite down on her arm in order to heal her wounds. After she'd recovered, Tsunade thanked Orochimaru and reluctantly admitted that he seemed to have changed since being sealed by Itachi, though she also noted that had he changed earlier, Jiraiya might have still been alive.

Just before they parted ways, Tsunade was shocked to find out that Katsuyu's other half was already on the battlefield, and she could in fact update them on the situation there. Tsunade fully healed her fellow Kage, and the group prepared to head back to the battlefield as soon as possible. Atop Gaara's sand, the Kage make their way to the battlefield. Upon seeing the enormous tree ahead of them, Tsunade inquired to Katsuyu about the current situation. While making their way there, Tsunade and the others are startled when a telepathic link was opened and she heard the voice of her grandfather who warmly greeted her. Through this method, she listened on as her grandfather explained the situation and what Madara's intentions were. Later, As Naruto's anger at the loss of his comrades he had fought so hard to protect grew, his emotions and memories were conveyed to everyone within the telepathic link. Tsunade sympathised with Naruto over the loss of Jiraiya and later viewed her grandfather's memories of the first ever Summit of the five Kage before arriving on the battlefield as Hashirama declared his wishes for the future of the world.

Noting that they needed to disperse across the battlefield immediately to keep the morale going, Tsunade's first act was to head over to where a chakra-depleted Shikamaru was and expedite his healing before commending Sakura for a job well done. Heading over to her grandfather, she apologised to him for the state of things, she then told him that he himself had no need to apologise either as it was not only the ills of the past that got carried into this generation, but good things such as his indomitable Will of Fire. With this, she called out to her troops to prepare to fight.

As the troops around her charged forward, she and Sakura remained behind. Releasing their Strength of a Hundred Seals, Tsunade noted that with two of them able to use the seal they would be able to summon one tenth of Katsuyu's main body from the Shikkotsu Forest. As the slug appeared on the battlefield and began to deconstruct, Tsuande noted that they could use Katsuyu's body in this form to create a recovery area where the shinobi could heal themselves and continue fighting.

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Tsunade was only seen in a Flashback when Naruto was in a prison cell with Yukie Kazahana trying to brak the chains that were holdind his arms together.

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Tsunade's voice is heard off seen during the opening of the movie. She seen Naruto,Sakura and Rock Lee on a B rank mission to protect Michiru and his son Hikaru.

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Tsunade sent out many advance teams to stall the stone army. Naruto Uzumaki, Sakura Haruno, Neji Hyūga and Rock Lee were sent to guard Shion, and deliver her to the shrine where Mōryō's body was sealed.

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Tsunade was reported by Kakashi about the mission, while worrying that the next ninja targeted will be him. Tsunade seems to not care so much, telling Kakashi to relax. At the hospital, Kakashi gives Naruto his bells, which they used for their first drill together, and tells him to fix them because he crushed them. Tsunade sent Konooha ANBU to Mount Shumisen to search the area for tracks of the missing kekkei genkai ninja. Tsunade is awaiting Gaara at a secret meeting place to discuss what shall be done. However, on the way there Gaara and his Sunagakure shinobi are attacked by a hawk, which traps them in an avalanche.

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Tsunade states that Naruto is wanted for attempting to assassinate the leader of Kumogakure, the Raikage, and killing jōnin from Kirigakure and Iwagakure so Team Kakashi placed him under arrest and taken to Hōzukijō, a criminal containment facility, also known as the "Blood Prison", in Kusagakure. She and all his friends have gathered there. Tsunade reveals that it was Naruto's mission to destroy the box and that no one believed that Naruto really committed any of the crimes.

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The movie starts with a flashback to the Nine-Tails' Attack on Konoha, which then flash forward to eight members of Akatsuki that are meant to be dead which unsettles Sakura. Shikamaru states there is no point in wondering why the dead are back alive and quickly comes up with a counter plan, but Naruto quickly attacks Akatsuki head on, forcing the rest of the Konoha 11 plus Sai, Kakashi and Guy to attack. The battle continues until Naruto is caught by Kakuzu, Sai frees Naruto by cutting part of Kakuzu's arm off, causing the Akatsuki to retreat. Naruto and his friends return home, where most of Naruto's peers are congratulated by their families whom all promise to write a recommendation letter so they can become jōnin although Sakura has a little fight with her family who embarrasses her in front of the others. As Naruto returns home, he passes many families causing him to reminisce of his father and mother causing him to get lonelier. He then asks Iruka for a letter of recommendation of his own, but Iruka refuses as Naruto is only a genin and must become a chūnin and rise through the ranks just as Minato and all other jonin did. Naruto is saddened by his lonely lifestyle and the fact no one seems to understand him, and storms off. He meets Sakura, who had an argument with her family and also stormed out, grabbing Naruto's hand and telling him to go on a date with her. While Sakura complains of her family, Tobi appears in front of them and after a small scuffle, he then activates the limited Tsukuyomi. Naruto and Sakura are absorbed in a flash of light, and later find themselves still in the same park they were before.

They run into their friends including Sasuke, but with different personalities and no one knows who Tobi is. They realize they are in another world where Sakura's father was the Fourth Hokage, who saved the village instead of Minato, and in this world Naruto is named Menma instead. As Naruto and Sakura return home Sakura is happy for the new freedom she has, while Naruto hurries home to his apartment hoping to see his parents, only to find he does not live there.

Tobi reveals that the dead Akatsuki members in the beginning were only Zetsu clones. In the Genjutsu World, a man in a mask meets Tobi and they agree to work together. Elsewhere, as Sakura is looking through her dresser, she sees the same coat that Naruto's father had worn. She then meets Sasuke who gives her a flower and flirts with her. Naruto and Sakura meet in the morning to try to gather more information of their current world, although Sakura enjoys this world as she has more freedom and is well loved by the village thanks to her father's actions. Naruto, on the other hand, wants to return home as fast as possible.

Naruto and Sakura meet Tsunade and Shizune who tells them that a masked man attacked Kumogakure, and killed their jinchūriki which Naruto and Sakura believe to have been Tobi. They then meet Naruto's parents who are alive. Minato says that Jiraiya died finding the Red Moon Scroll that was said to help save the world. Tsunade lets Naruto and Sakura join Minato and Kushina on their mission when Kakashi and Guy return. Sakura is shocked at finding out who Naruto's parents are, while Naruto is angry that Tobi would dare to make copies of his dead parents and he swears to break the Genjutsu. While Sakura is still enjoying her life, she wonders how Naruto is doing. While Naruto attempts to ignore his parents, he sees an album showing him, how his life would have been if his parents had been alive.

In the morning, Sakura notes that this world's Kakashi and Guy switched personalities, while Naruto isolates himself from his parents at every turn. They soon locate where Jiraiya hid the scroll, but as the group stops to rest Naruto charges ahead until he is confronted by the summoning of Gamabunta, Gamahiro and Gamaken. They refuse to listen to Naruto and the group who explains their reason for being there and attacks them with an army of frogs. Naruto attempts to use Sage Mode, but is unable to gather enough energy before Gamabunta attacks him. Kushina protects him, but hurts herself from a shot of acid that burns Kushina's leg. Minato saves both of them and quickly is able to get the scroll, unsummoning the toads.

As Sakura heals Kushina, Naruto still attempts to brush off his parents, causing Minato to say no matter what Naruto does, they will always try to save him. Kushina then awakens and hugs Naruto, causing him to be unable to try to ignore his parents any longer and finally accepts them. They return to Konoha, where Tsunade locks the scroll in the villages Safe up till the night when a red moon will appear when they can use the scroll to fulfill the said prophecy. As Naruto and Sakura walk home, Naruto quickly walks home leaving Sakura alone and happily walks into his house. She instead finds her home too lonely and wonders if Naruto's always this alone. As she walks down town she sees happy families, only making her more sad. She then realizes that this world's Sasuke is just a flirt and decides that Naruto was right on his decision to quickly break the genjutsu they're now trapped in and wishes to return to their own world. As she walks to Naruto's home to try to find a way to break the genjutsu, she see how happy Naruto is and wonders should they leave. Sakura later meets Naruto, and asks him if he wants to stay. Although he denies it, he later thinks to himself that he truly does not want to leave.

At that moment an explosion occurs at the Hokage's office, where the masked man from earlier asks for the scroll they brought back. He overpowers Minato, Kushina, and Tsunade, till Naruto and Sakura arrive. They realize that this was the man Tsunade was talking about, and that he knows Tobi. He overpowers Naruto and Sakura, and kidnaps Sakura in exchange for the scroll. He then uses Great Spiralling Ring, destroying a large part of Konoha and leaves. Naruto tries to save Sakura, but Minato prevents him, showing that in the end this world's Minato is different from his father. He takes one of Minato's kunai and the scroll leaving with Sakura's father's Hokage coat. Sakura is tied up and meets Tobi who is a ghost saying they are in an old training ground that Minato and Jiraiya used. Naruto arrives but is attacked by the other masked man asking for the scroll. Naruto is unable to fight properly as his stomach acts up, the Masked Man then takes the time to summon the Nine Masked Beasts, and about to kill Naruto when the Akatsuki arrives and saves him.

This Akatsuki was hired by Tsunade to help Naruto, and they deal with the masked beasts when Naruto attacks the masked man. Itachi saves Sakura and Tobi decides to escape instead. The Akatsuki defeats the masked beasts that turn into nine fox kits, while Naruto chased the masked man into the training grounds. They then fight, Naruto uses Sage Mode and uses the Wind Release: Rasenshuriken to counter the Masked Man's Great Spiralling Ring. It ends in a draw, but the attack destroy the masked man's mask, showing that he is Menma, this world's Naruto. Menma then called back the defeated masked beasts, and summoned Kurama's counterpart, the Black Nine-Tails. Naruto was unable to attack, while the Akatsuki retreat, taking Sakura with them. Not wanting to be manipulated by the Sharingan again, Kurama makes a truce with Naruto to work together, allowing him to summon Kurama out of his body. In the battle Naruto is barely able to win, but Tobi reveals that this was his plan, to have Naruto and Menma fight, as doing so would cause the two foxes to fight and weaken Kurama. As he possessed Menma, Kurama warned Naruto if he looked into Menma's Sharingan, it would be all over for Tobi planned to extract Kurama out of Naruto the same way he extracted it from Kushina 16 years ago. Naruto tries to use the scroll when he notices the moon had turned red, but Menma cuts the scroll, causing Naruto to look in Menma's eyes. Naruto's memories were erased, but Sakura rescues him.

Naruto, in an anesmia state looking at half of the scroll, is able to remember Jiraiya and his memories. He then defeats Tobi the same way his father did breaking the Limited Tsukiyomi. Tobi using his ghost body tries again, till Minato and Kushina arrive. Tobi decides to give up and exits the genjutsu world just as Naruto and Sakura are enveloped in a bright light preparing to return to their world as well, but beforehand Naruto thanks Minato and Kushina who quickly goes to assist Menma who is returning to his original state as their son. Naruto and Sakura returns to their world, where Naruto's Hokage coat breaks down since it was only part of the genjutsu world and not real. Naruto and Sakura tell Tsunade and Kakashi of what transpired and sets out more guard patrol since Tobi was easily able to enter further in the village than they imagined. As they both return home, Naruto watches Sakura as she meets her parents, happily hugging them, he approaches her asking her out on a date, but Sakura tells him they just came back from the longest date ever, causing Naruto's shock. As Naruto goes home, he sees Iruka in his house, waiting to apologise to him. Iruka shows Naruto a cake,and Naruto shocking cries after he realizes that Iruka really does care about him. Iruka asks him what's wrong,and Naruto says nothing. Iruka welcomes Naruto home,and Naruto says I'm home. Afterwards Naruto happily walks through the village while quoting that the road of a ninja is one who endures.

Video Games
Tsunade is a playable character in the following video games:
 * Jump Ultimate Stars
 * Naruto RPG 2: Chidori vs Rasengan
 * Naruto Shippūden: Clash of Ninja Revolution 3
 * Naruto Shippūden: Gekitō Ninja Taisen! EX 2
 * Naruto Shippūden: Gekitō Ninja Taisen! EX 3
 * Naruto Shippūden: Gekitō Ninja Taisen! Special
 * Naruto Shippūden: Ninja Council 4
 * Naruto Shippūden: Ninja Destiny 2
 * Naruto Shippūden: Ninja Destiny 3
 * Naruto Shippūden: Ultimate Ninja 4
 * Naruto Shippūden: Ultimate Ninja 5
 * Naruto Shippūden: Ultimate Ninja Heroes 3
 * Naruto Shippūden: Ultimate Ninja Storm 2
 * Naruto Shippūden: Ultimate Ninja Storm 3
 * Naruto Shippūden: Ultimate Ninja Storm Generations
 * Naruto Shippūden: Ultimate Ninja Storm Revolution
 * Naruto: Clash of Ninja Revolution
 * Naruto: Clash of Ninja Revolution 2
 * Naruto: Gekitō Ninja Taisen! 3
 * Naruto: Gekitō Ninja Taisen! 4
 * Naruto: Ninja Council 3
 * Naruto: Ninja Destiny
 * Naruto: Path of the Ninja 2
 * Naruto: The Broken Bond
 * Naruto: Ultimate Ninja 2
 * Naruto: Ultimate Ninja 3
 * Naruto: Ultimate Ninja Heroes
 * Naruto: Ultimate Ninja Heroes 2: The Phantom Fortress
 * Naruto: Ultimate Ninja Storm

Quotes

 * (When about to fight Naruto) "One of the Legendary Sannin taking on a snot-nosed genin… I oughta be ashamed of myself."
 * (To Jiraiya about Naruto) "Jiraiya, are you the one who taught him the Rasengan? Are you acting like a teacher by teaching him something he can't master? Don't give him any ideas! That's why this kid likes to daydream that he's going to become Hokage someday."
 * (To an unconscious Naruto) "It's because to be Hokage… is your dream… isn't it Naruto? One last time… just one last time… I place the odds on you."
 * (To Orochimaru) "From now on… I too shall bet my life!"
 * (To Orochimaru) "Why am I putting my life on the line? Because now… I am the Fifth Hokage of Konohagakure!"
 * (To Shikamaru) "Grow up… Death comes with being a shinobi… There are times when death is hard to accept, but if you don't get over it, there's no future…"
 * (To the advisers) "People like Jiraiya… and Sarutobi, and Elder Chiyo of Suna possessed something you two sorely lack. Do you know what that is!? …Faith! My grandfather, the First Hokage, believed in you and entrusted you with the village. Now it's your turn to believe in these children and entrust it to them!"
 * (To Pain) "I am the Fifth Hokage… You've trampled on our ancestors' treasure… their dream… And you will pay the price! As the Hokage, I will put a stop to you here and now!"
 * (To Shizune) "People become stronger because there are memories that they will not forget."
 * (About her bad gambling) "Only when it comes to money. My life is a different story. I'm still alive aren't I…?"
 * (To Madara) "Although I am a descendant of the First Hokage, it's true that I don't know how to use Wood Release. And compared to him, who was able to use medical ninjutsu without even making seals, it's true that my own ninjutsu is nothing to brag about. And it's true that I'm a woman… but I'm definitely not a weak woman… What I inherited from my grandfather isn't just simple 'power'. My true strength comes from that which was passed down from the First to each generation afterward… Don't underestimate the Will of Fire!"

Knownable Relatives

 * Senju Hashirama (Grandfather/decreased)
 * Uzumaki Mito (Grandmother/decreased)
 * Senju Tobirama (Granduncle/decreased)
 * Nawaki (Little Brother/decreased)
 * Kato Dan (Boyfriend/decreased)
 * Shizune (Stundent)
 * Haruno Sakura (Medical Student)
 * Uzumaki Naruto (Rival)
 * Jiraiya (Teammate/decreased)
 * Orchimaru (Teammate)

Trivia
According to the databook(s):
 * "Tsunade" (綱手) means "mooring rope", which is not dissimilar to her brothers name, Nawaki, which means "rope tree". A similar word "tsundere" (ツンデレ), could also be a play on Tsunade's personality.
 * Tsunade shares the same blood type with Naruto,including her former team-mates, Jiraiya and Orochimaru.
 * Tsunade was the first female Hokage, as well as the first female Kage, that appeared in the series.
 * Tsunade is first mentioned when Might Guy questions Rock Lee, Neji, and Tenten about their goals as genin. Tenten says that she wants to become a great kunoichi and follow the footsteps of the legendary Tsunade.
 * Tsunade's hobby is gambling'.
 * Tsunade wishes to fight Uzumaki Naruto.
 * Tsunade's favourite foods are chicken breast and sake, while her least favourite food is liver sashimi.
 * Tsunade has completed 1,256 official missions in total: 40 D-rank, 236 C-rank, 467 B-rank, 418 A-rank, 95 S-rank.
 * Tsunade's favourite phrase is "One grab, a thousand gold" (一攫千金, Ikkaku Senkin), referring to getting rich without much effort.
 * While Tsunade's English anime voice actor is Debi Mae West, in most games she is voiced by Mary Elizabeth McGlynn, who is Yuhi Kurenai's voice actor. The few games where she is voiced by her anime voice actor are Naruto Shippūden: Legends: Akatsuki Rising, Naruto: Uzumaki Chronicles 2, Naruto: Clash of Ninja Revolution, and Naruto Shippūden: Clash of Ninja Revolution 3. In Naruto: Clash of Ninja Revolution 2, while being voiced by Mary Elizabeth McGlynn throughout the story-line, during game-play, most of Debi Mae West's voice-overs from the first game are still used.
 * Tsunade's grandmother, Uzumaki Mito had a similar diamond shape mark on her forehead. It is possible that Tsunade modelled her own seal after this.

Voice Actresses

 * Japanese : Masako Katsuki (Teenager and Adult), Haruchi Terada (Child)


 * English : Debi Mae West (Teenager and Adult), Mary Elizabeth McGlynn (Child)